Kim, A. R., Kim, J. H., & Park, J. H. (2025). Clinical Efficacy of Dual-Task Cognitive Training Combined With Transcranial Direct Current Stimulation in Older Adults. 재활치료과학, 14(4), 45-59.

•논문구분: 국내저널

•학술지명: 대한신경계작업치료학회

•논문제목: Clinical Efficacy of Dual-Task Cognitive Training Combined With Transcranial Direct Current Stimulation in Older Adults

•ISSN: 2671-4329

•DOI: https://doi.org/10.22683/tsnr.2025.14.4.045

•주저자명(제1저자): Ah-Ram Kim

•공동저자명: Jong-hyeon Kim, Ji-Hyuk Park

•볼륨번호(권,호): 14권 4호

•SCI(E)구분: KCI(후보지포함)

•논문페이지: 45-59

•학술지 임팩트팩터: -

•학술지 출판일자: 2025.11.30

•초록:

Objective: To examine the effects of dual-task cognitive training combined with transcranial direct current stimulation (tDCS) on cognitive and daily functioning in older adults. Methods: Ten older adults participated in an eight-session dual-task cognitive training program combined with tDCS. Pre- and post-intervention assessments measured cognitive function, activities of daily living, attention, and brain activity using validated tools. Results: Post-intervention analyses showed significant improvements in cognitive function (measured by the Comprehensive Item Selection Test and the Korean version of the Montreal Cognitive Assessment), instrumental activities of daily living (measured by the Korean version of the Instrumental Activities of Daily Living scale), and reduced cognitive decline (measured by the Global Deterioration Scale) (all p < .05). No significant changes were observed in attentional control (measured by the Attentional Control Questionnaire) or in the accuracy and reaction times on the N-back and Stroop tasks. Conclusion: Combined dual-task cognitive training and tDCS may improve cognitive function and activities of daily living in older adults. Further research is warranted to validate and optimize this intervention. progression from mild cognitive impairment to Alzheimer's disease dementia, remains controversial. To evaluate the association between aspirin, use and the risk of conversion to Alzheimer's disease dementia among individuals diagnosed with mild cognitive impairment.Methods In this retrospective population-based cohort study, we used the Korean National Health Insurance Service database to collect data on patients with mild cognitive impairment enrolled between 2013 and 2016 and followed up until 2021. In total, 508,107 patients initially diagnosed with mild cognitive impairment (192,538 with aspirin prescriptions and 315,569 without aspirin prescriptions) were enrolled. Aspirin use was assessed by extracting information from the Korean National Health Insurance Service database using aspirin prescription codes. The primary outcome was newly diagnosed Alzheimer's disease dementia. Hazard ratios and 95% confidence intervals for Alzheimer's disease were analyzed according to aspirin use using Cox proportional hazards regression analysis. Secondary outcomes included ischemic and hemorrhagic stroke risk associated with aspirin use.Results The data of 508,107 individuals were analyzed (mean [standard deviation] age, 67.6 [10.7] years; 66.8% women and 33.2% men), and 39,318 developed Alzheimer's disease (22,572 controls and 16,746 using aspirin). The rate of conversion to Alzheimer's disease was lower in the aspirin user group, and the time to Alzheimer's disease dementia occurrence was longer than in the nonuser group. A decreased Alzheimer's disease dementia risk was found in patients using aspirin in Model 2 (adjusted hazard ratio, 0.939; 95% confidence interval, 0.920-0.959), with more pronounced effects in individuals aged >= 65 years (Model 2 adjusted hazard ratio, 0.934; 95% confidence interval, 0.914-0.955). For hemorrhagic stroke, the risk increased with aspirin use across all age groups, with the highest risk observed in younger patients (Model 2 adjusted hazard ratio, 5.082; 95% confidence interval, 4.838-5.341).Conclusion Aspirin use was associated with reduced Alzheimer's disease risk in older patients with mild cognitive impairment. Notably, the bleeding risk associated with aspirin use should be considered, and personalized treatment should be provided.